Drug Discovery Research Screening Libraries
AdipoGen BFC
Chemical. CAS 220001-53-6. Formula C17H11F3O3. MW 320.3. 7-Benzyloxy-4-trifluoromethylcoumarin is a fluorescent substrate for cytochrome P450 family members CYP1A2, CYP3A4 and potentially others. Has been used in high-throughput screens in fluorometric p450 activity assays and is metabolized to the fluorescent metabolite 7-Hydroxy-4-trifluoromethylcoumarin HFC with lambdaex=410nm lambdaem=530nm.
AdipoGen 3-cis-Hydroxyglibenclamide
Chemical. CAS 23074-02-4. Formula C23H28ClN3O6S. MW 510. Synthetic. M2-Metabolite of the antidiabetic compound glyburide. Antidiabetic reagent. Shows 50% hypoglycaemic activity of the parent compound, by increasing insulin secretion. Compound can be used as analytical reference material.
AdipoGen 4-trans-Hydroxyglibenclamide
Chemical. CAS 23155-00-2. Formula C23H28ClN3O6S. MW 510. Synthetic. A key active metabolite of the antidiabetic compound glyburide.
AdipoGen MOTS-c K14Q Mutant human
Chemical. Formula C100H148N28O23S2 . C2HF3O2. MW 2174.6 . 114.0. Synthetic. The mitochondria-derived peptide MDP MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase AMPK. It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity DIO in mice. This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.
AdipoGen Melatonin
Chemical. CAS 73-31-4. Formula C13H16N2O2. MW 232.28. Melatonin is an endogeneous hormone that plays a prominent role in the control of circadian rhythm that displays anti-inflammatory, anti-obesity, anti-cancer, bone-protective, cardiovascular, immunomodulatory, neuroprotective and antipoxidant free radical scavenging properties. Melatonin functions as a glycolytic since it inhibits the Warburg effect. Melatonin may have advantages over the synthetic glycolytics since it is an endogenously synthesized molecule in every organism including in the human. Melatonin is also a mitophagy regulator. It seems to exert an essential effect on mitochondrial physiology and facilitates mitochondrial function. A central mechanism by which melatonin protects mitochondria is by restoring the MMP through blocking mPTP opening under stress and activating uncoupling proteins UCPs to marginally decrease MMP under normal conditions.
Alkali Scientific Radiant™ Library Quant Kit for Illumina Separate ROX, w/ Standards, Primers & Buffer, 100 x 20μL Reactions
Radiant™ Library Quant Kit for Illumina Separate ROX, with Standards, Primers & Buffer. Includes 100 x 20μL Reactions. This kit is optimized for Illumina platforms using Separate ROX, providing highly accurate and reproducible results for next-generation sequencing. The carefully balanced combination of primers, standards, and buffer allows for precise library quantification, making it suitable for a wide range of genomic and sequencing applications.
AdipoGen DRibose
Chemical. CAS 50-69-1. Formula C5H10O5. MW 150.13. Synthetic. Aldopentose monosaccharide that is phosphorylated into D-ribose 5-phosphate by ribokinase. D-ribose-5-phosphate supports the biosynthesis of the amino acids tryptophan and histidine, and is a component in the pentose phosphate pathway. D-ribose is present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways. It also participates in the glycation of proteins producing advanced glycation end products AGEs that lead to cell dysfunction and death. Ribosylation, has been shown to cause protein aggregation in vitro and in vivo. Has demonstrated significant enhancing abilities in replenishing deficient cellular energy levels following myocardial ischemia, improving depressed function in numerous animal investigations and showing cellular protection during oxidative stress.
AdipoGen Isthmin-1 mouse rec
Recombinant Protein. Mouse isthmin-1 aa 30-461 is fused at the C-terminus to a His-tag. .Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test.. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. Isthmin-1 ISM1 was first identified as a gene expressed in the Xenopus midbrain hind brain organizer called isthmus, with a proposed role during early brain development. Isthmin-1 encodes a predicted ~50-kDa protein containing a signal peptide, a thrombospondin domain and an adhesion-associated domain. Isthmin-1 is important for embryonic and postnatal development. Growing evidence has shown that aberrant expression of Isthmin-1 can also affect the biological behavior of cancer. The Ism1 gene is conserved in mice and humans. A recent study showed that Ism1 is an adipokine that induces glucose uptake in human and mouse adipocytes.
Enzo Life Sciences SCREEN-WELL Hepatotoxicity library (100µl/well)
The SCREEN-WELL Hepatotoxicity Library is a focused collection of 238 compounds with defined and diverse hepatotoxicity, including steatosis, mitochondrial toxicity, Mallory body formation, cholestatic effects, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development. Long Term Storage: -80°C. Applications: HTS .
AdipoGen 4-trans-Hydroxyglibenclamide
Chemical. CAS 23155-00-2. Formula C23H28ClN3O6S. MW 510. Synthetic. A key active metabolite of the antidiabetic compound glyburide.
Apexbio Technology LLC DiscoveryProbe™ Autophagy Compound Library Plus, 100uL/well(10 mM solution),96 Well Racks With Screw Cap
DiscoveryProbe™ Autophagy Compound Library Plus is a unique collection of 837 autophagy-related compounds for autophagy research. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
Enzo Life Sciences SCREEN-WELL Purinergic ligand library (500 µl/well)
The SCREEN-WELL Purinergic and Adenosine Ligands Plate contains 72 CNS receptor ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Purinergic and Adenosine Ligands Plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 ligands. Long Term Storage: -80°C. Applications: HTS .
AdipoGen Rebaudioside A
Chemical. CAS 58543-16-1. Formula C44H70O23. MW 967.01. Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a alpha-glucosidase inhibitor with IC50=35µg/ml and can inhibit ATP-sensitive K-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 GLP-1 secretion in a 2-dimensional mouse intestine model. Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent.
AdipoGen bpVHOpic
Chemical. CAS 722494-26-0. Formula K2VOO22C6H4NO3. MW 347.2. Potent protein phosphotyrosine phosphatase inhibitor. Insulin mimetic. PTEN inhibitor.